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The underlined mechanism involves CGA-mediated excessive ROS production, causing mitochondrial dysfunction, leading to increases in cleaved levels of caspase-3, caspase-9, PARP, and Bax/Bcl-2 ratio [297,298]

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doi: 10.1186/s12964-020-00543-8

12 Letrozole has similarly been shown to improve testosterone-to-estrogen ratios and semen parameters in infertile men
Mutating any of these three residues has been shown to completely abolish both the lipase and esterase activities of MGL (57)
