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This induction was similarly observed in lipid-laden, PPAR-KO fasted livers (Figure 1C)

Therefore, more recent research has shifted the focus to screening a drug that targets the lipotoxicity of individuals with fewer side effects to prevent and treat KOA [10, 11]

For example, L-carnitine L-tartrate, due to its rapid absorption, could allow for quicker effects, especially when taken before exercise

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However, study of the roles of these LDL subclasses, such as sdLDL, in the development of ASCVD is not easy because distinct methods may obtain different LDL subclasses with distinct physiochemical properties