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Once inside the cell, the fura-2 ester is hydrolyzed by cytosolic esterases to its non-lipophilic form, and then the dye cannot diffuse back out of the cell

J Clin Endocrinol Metab 00:113

It has also been shown that P-selenoprotein protects lipoproteins against oxidation by removing the peroxynitrite molecule that is formed due to oxidative stress within cells as a result of the reaction between superoxide ions with nitric oxide molecules at sites of inflammation [17,18,19]

In fact, silymarin has been shown to increase glutathione levels in the stomach and intestines in addition to the liver
