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S-adenosylhomocysteine (SAH) is generated as a product of transmethylation and is hydrolyzed to form homocysteine (Hcy) and adenosine through a reversible reaction catalyzed by SAH hydrolase

The prominent feature of OIPN is the presence of sensory peripheral neuropathy, including dysesthesias, numbness, and sensory loss in a distribution resembling a stocking-and-glove pattern, which is possibly concomitant with neuropathic pain and infrequent motor and/or autonomic damage (Argyriou et al., 2007

doi:10.1016/S0736-0266(03)00117-7 32

Using state-of-the-art equipment, our practitioners carefully select an appropriate vein for catheter insertion, prioritizing patient comfort and minimizing any potential discomfort

In the future, the development of double-acting drugs that act via the TRP channels and reduce cytokine release will be necessary for the treatment of OX-IN