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What Research Shows (Up to 12 Weeks): Chronic toxicity : None documented (studies up to 12 weeks) Organ damage : None detected in histopathological examination Carcinogenic effects : None observed (though dedicated cancer studies haven't been done) Reproductive toxicity : None found in limited fertility studies What We Don't Know: 1

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Cadmium affects tobacco cells by a series of three waves of reactive oxygen species that contribute to cytotoxicity

Thus, there is little data from which to draw conclusions about its safety, especially regarding long-term use in humans [2]

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma