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These enzymes work faster in the presence of oxidative stress or infections, which increases the need for hydroxocobalamin

For example, in muscle, IRS-1 is more related to glucose uptake whereas IRS-2 stimulates the MAPK pathway [121]

High-dose B12 supplements, even 1,000 mcg daily, are generally safe because the body uses what it needs and excretes the rest

Mechanism of action [edit] Vitamin B 12 refers to a group of compounds called cobalamins that are available in the human body in a variety of mostly interconvertible forms
