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In this work, the molecular mechanisms of resistance to cisplatin were investigated, focusing on DNA repair and NRF2/GSH pathways

Hemolysis with an increased rate of red blood cell destruction is commonly due to inherited blood disease but can also be acquired or due to infection, including: Thalassemia is a genetic blood disorder caused by defective hemoglobin synthesis in red blood cells, resulting in fewer red blood cells, a shorter lifespan, and easily broken-down red blood cells

Pattern recognition receptor (PRR)-dependent pathway: cholesterol-rich microdomains exposed on the crystal surface directly bind to Toll-like receptors 2/4 (TLR2/4), thereby initiating the MyD88 signaling cascade (Narang and Dalbeth, 2020)

APAP PHARMACOKINETICS IN CHILDREN As has been observed with many other drugs, the variability in APAP PK varies with age from birth to adulthood

doi: 10.1111/j.1476-5381.2011.01631.x