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Multicenter trial of Incarnitine in maintenance hemodialysis patients: I

doi: 10.1001/archpedi.1987.04460060076039

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How to Use: Mix one sachet with water or juice and consume once daily or as directed by a healthcare professional

CDCA is an endogenous ligand for FXR, and its activation can reduce lipid absorption in intestinal cells and control lipid synthesis in liver cells ( in vitro studies have shown that simvastatin undergoes bioaccumulation in gut bacteria and is biotransformed by bacterial enzymes (e.g., from Lactobacillus and Bifidobacterium ), leading to delayed absorption and reduced concentration of simvastatin (71), ultimately weakening the lipid-lowering efficacy of simvastatin