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Most patients with NAFLD are asymptomatic, and the diagnosis is mainly made incidentally on the basis of liver biochemistry or abdominal ultrasound abnormalities

Patients with chloasma exhibit significantly higher permeability of CD4+ T cells, CD68+ macrophages, and mast cells in skin lesions compared to healthy individuals (150)

These findings have led to new efforts to understand the aetiology of diabetic neuropathy, along with new 2017 recommendations on approaches to prevent and treat this disorder that are specific for each type of diabetes

doi: 10.1038/s41586-023-06034-3 51 ElseaSHRazjouyanJLeeKMLynchJAMartiniSPanditLM
