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Description
In vitro, C16-carnitine has been found to activate specific subsets of neurons in the dorsal root ganglia (DRGs) of muscles that play a key role in sensing muscle fatigue or exertion and are involved in transmitting these sensory signals to the CNS, indicating that C16-carnitine acts as a signaling molecule for muscle afferent nerves [281]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Aversa A, Bruzziches R, Pili M, Spera G

It's noted that high doses of oral L-carnitine can increase TMAO levels in the bloodstream, which is associated with cardiovascular risks

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