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In one randomized trial involving patients with SARS-CoV-2, olive leaf capsules, rich in phenolic compounds such as AC, luteolin-7-glucoside, apigenin-7-glucoside, hydroxytyrosol, and oleuropein were shown to reduce viral load and improve several clinical biomarkers, including complete blood count (CBC), C-reactive protein (CRP), ferritin, erythrocyte sedimentation rate (ESR), and lactate dehydrogenase (LDH) after 10 days of treatment (ClinicalTrials.gov Identifier: NCT04873349)

doi: 10.1186/s12916020-01587-w 202 TraberMGStevensJF

Nicotine acetylcholine receptors (nACHRs) (Ni et al., 2013) and using an antagonist of 7nAChR can actually inhibit the proliferation of microglia and reduce the expression of inflammatory factors IL-1 and TNF- (Poorthuis et al., 2009), improves neuronal plasticity in the hippocampus (Motaghinejad et al., 2016), and can treat excitotoxicity at low concentrations (Sieber, 2012)