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Under hypoxia conditions, the inactivation of hydroxylase results in the intracellular accumulation of HIF-1, HIF2, and ARNT to form heterodimers, which regulate cellular adaptation to hypoxia and survival

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Christensen B, Arbour L, Tran P, Leclerc D, Sabbaghian N, Platt R, Gilfix BM, Rosenblatt DS, Gravel RA, Forbes P et al

Western blot analysis and Coomassie Brilliant Blue (CBB) staining Samples were boiled in sample loading buffer at 100 C for 10 min, separated by SDS-PAGE, and transferred onto NC membranes for blotting

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