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In DCM, lysosomal dysfunction is commonly observed, including increased membrane permeability, a decreased number of acidic lysosomes, and impaired autophagosomelysosome fusion efficiency (Figure 4)
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The remaining 12 patients were included and operated on sequentially to limit risk in this in-human study (Extended Data Fig
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155 Moreover, gastric cells exposed to 13-HODE increased the production of branched chain amino acids, suggesting a possible beneficial impact of oxidized oil consumption
