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Specifically, we hypothesized that ALCAR/ALA, but not placebo, at both week 1 and week 12, would produce increased cerebral concentrations of phosphocreatine (PCr), a compound that serves as a reservoir for high-energy phosphates, and -nucleoside triphosphate (-NTP), which is widely acknowledged as the best index of brain levels of adenosine triphosphate (ATP)

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Similarly, isoleucine-derived 2-methylbutyryl-CoA ultimately yields acetyl-CoA and succinyl-CoA, while the catabolism of valine-derived isobutyryl-CoA yields propionyl-CoA (Adeva-Andany et al., 2017)