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In the central nervous system (CNS), inflammation is considered as a common mechanism in neurodegenerative diseases, characterized by activation of astrocytes and microglia in response to brain injury

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The Hippo pathway, critical for liver regeneration, comprised of MST1/2 phosphorylating and activating the LATS1/2, which then phosphorylates and inactivates YAP and TAZ

Thus, when diseases of pre-puberty result in production of ROS through, for example, a protective inflammatory response, the consequence would be survival to reach a reproductive age

A comprehensive search was undertaken in PubMed, Web of Science, and EMBASE for studies published between January 2020 and July 2025 to ensure inclusion of the most recent evidence