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What the research shows: A phase 2 randomized, double-blind, placebo-controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023) enrolled 338 adults with obesity

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The American Diabetes Association Standards of Care emphasizes the importance of resistance training and adequate protein intake during pharmacologic weight loss to maintain muscle mass, and creatine supplementation may support these goals

Studies have also examined it in models involving neuropathic and metabolic stress responses