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However, the clinical application of PDK inhibition must be approached cautiously, as systemic toxicity may arise from off-target effects in vital organs that rely on PDK-mediated metabolic regulation for physiological homeostasis
Often the response in the target cell is an intracellular message, sometimes called a second messenger, that is recognized by another internal receptor and initiates another response
World Psychiatry 16 , 308315 (2017)
