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These processes play a crucial role in the biological mechanisms that drive tissue development, such as the regulation of cell polarity, gene expression and stem cells differentiation (Smith et al., 2018)

In Hashimotos thyroiditis (HT), major sources of oxidative stress include misfolded proteins, dysbiosis and molecular mimicry, self-tolerance defects linked to AIRE gene dysfunction, and irregularities in thyroid protein folding (da Silva et al

446 Interestingly, a post-hoc analysis indicated that baseline serum lactate dehydrogenase (LDH) levels could be a potential predictive factor for treatment response

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