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Importantly, signaling pathways such as Nrf2/HO-1, NF-B, PI3K/Akt/mTOR, XO/NLRP3, Wnt/-catenin, FXR, TGF-1/Smad3, AMPK/SREBP, PPAR/, MAPKs, Caspases, and JAK2-STAT3 are considered critical targets through which API exerts its hepatoprotective effects

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Furthermore, we highlight that relatively simple dietary modifications can produce meaningful microbiome and metabolite shifts, particularly in elderly and metabolically compromised populations, where the microbiome may be more responsive to intervention, and intervention effects are more pronounced