glutathione synergy neurometabolic integration Frontiers Three-dimensional network of creatine metabolism:

Primer sequences have been listed in table 1

Abbreviations: CCC: Clear-cell carcinoma, TNBC: Triple Negative Breast Cancer, Trx: thioredoxin, Grx: glutaredoxin

Oxidative stress plays a pivotal role in the pathogenesis of ACS [73,74]

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Furthermore, in spite of the aggressive and metastatic nature of triple-negative breast cancer (TNBC) [25], commonly treated with Pt(II)-based therapies, the few existing metabolomic reports have, to our knowledge, only addressed sensitive cell lines, to describe the impact of cDDP (namely on MDA-MB-231, MDA-MB-468 or SUM-159PT cell lines), compared to other agents such as tamoxifen, doxorubicin and a Cu(II)-chelate [26,27,28]