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49:37 Mark tries to have fun when moving (rather than managing pain as part of his training) 49:46 Activities of choice are stand up paddling, fat bike , foiling , snowboarding, and ultimate frisbee (that he plays with 20 somethings, some of whom won gold in the last world championships ) 51:44 The importance of balance as we age 55:46 To achieve longevity, find some form of resistance exercise, but try to make it fun 57:06 Slack line is great for balance 57:37 Mark has a new book, out in December 2019, Keto for Life , which covers his four pillars of longevity metabolic flexibility, movement & physical activity, mental flexibility, and rest & recovery and looks at how we can set ourselves up to live a longer, happier, healthier life with the least amount of pain, suffering, sacrifice and discipline

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p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy