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The signaling pathway involving receptor activator of nuclear factor-B ligand (RANKL), its receptor (RANK), and osteoprotegerin (OPG) plays a pivotal role in the regulation of bone resorption

Vitamin B12 deficiency is very common because it requires intrinsic factor which is a substance secreted by the stomach that enables the body to absorb vitamin B12

The passenger strand is conjugated to a triantennary N -acetylgalactosamine (GalNAc) carbohydrate

Acknowledgements This work was supported by the Medical Research Council (Future Leaders Fellowship MR/S031812/1), by the Ministry of Education, Culture, Sports, Science and Technology of Japan (Grant-in-aid for Scientific Research on Innovative Areas 26116713 (J.-M.F.)