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Earlier clinical trials of ovarian cancer vaccines showed limited efficacy often linked to inadequate immune responses (Nishida et al., 2022

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Mouradian M

In catalase-overexpressing cells, these antiproliferative responses were found to be the result of decreased activities in cyclin-dependent kinases (cdk) caused, in part, by the upregulation of Cdk inhibitors p21 and p27 (278)

However, intracellular GSH content was significantly increased in the multiple combination strains of these three genes, with GSH content exceeding 8.41-fold of the WT in all three multiple combination strains, and reaching 10.93-fold of the WT in the strain expressing all three genes simultaneously
