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The extra N-terminal Tyr residue is thought to help to stabilize the peptide

doi: 10.1210/clinem/dgad212 166 KotsifakiAMaroulakiSKaralexisEStathakiMArmakolasA

8,15 Serum holotranscobalamin level, which is reduced in vitamin B 12 deficiency, compared favorably with homocysteine and methylmalonic acid levels as a confirmatory test in one study, but further trials are needed before its widespread use for this purpose can be recommended
