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Injury to the peripheral nervous system causes hyperactivity of ACC neurons and upregulation of Piezo1 expression, thus supporting the involvement of Piezo1 channels in pain information transmission
Inhibition of the activation of inflammatory cells and the release of inflammatory mediators via the reduction of LPS had positive effects for the improvement of ALD in animal models

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MDA, the product of lipid peroxidation, is generated in excessive amounts, supporting the fact that large quantities of membranebound iron are present in thalassemia RBCs [22,23].Several studies have shown that MDA is a marker to determine the existence of oxidative stress [24-26]
Dietary interventions, particularly the intake of omega-3 PUFAs, have been shown to modulate lipid metabolism and reduce lipid peroxidation, making them potential adjuncts to ferroptosis inhibition (Mortensen et al., 2023)
