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According to Mayo Clinics drug and supplement reference, intramuscular B12 (the form used in MIXTs B12 injection protocols) is well-established for restoring B12 status quickly in clinically deficient patients and is often used when oral supplementation is poorly absorbed

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Subsequent peer-reviewed preclinical studies have examined its use as a tool compound for investigating NNMT enzyme activity in adipose, liver, and skeletal muscle cell-based research models under controlled laboratory conditions

If you do have a vitamin B12 deficiency, it will show up in different dermatological areas

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