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Capacity to utilise iron from transferrin or from haptoglobin-bound haemoglobin has been associated with invasive Haemophilus spp
The hyperpigmentation related to vitamin B12 deficiency is more common in darker-skinned patients

2020 safety paper is considered essential reading for any researcher evaluating this compounds translational potential

JAMA 2009;302:97784

Many, but not all of these cases, have shown a positive response to treatment with vitamin B12, based on improvements in abnormal metabolite levels and clinical indices (Stabler et al., 1990)
