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This contrasts with its role in pulmonary fibrosis, where its primary cellular targets are likely activated fibroblasts and alveolar epithelial cells, highlighting how curcumins efficacy is shaped by the unique cellular ecosystem of each diseased organ

K.DuaK.et al (2022)

2014 doi: 10.1016/j.freeradbiomed.2014.07.037

It penetrates the outer skin layers and acts locally on skin cells, fibroblasts, and the extracellular matrix

A common mutation in methylenetetrahydrofolate reductase gene among the Japanese population
