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Despite ROS having negative effects such as triggering apoptotic cell death (Redza-Dutordoir and Averill-Bates 2016), they also appear to be important for brain functions such as neuronal plasticity and memory (Hidalgo and Arias-Cavieres 2016)

On the other hand, Treg cells are adapted to lipid peroxide-enriched TME, and tumoral PMN-MDSC release oxygenated lipids to limit T cell activity to promote tumor growth

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doi: 10.1053/hupa.2001.28947 58 GordonJRGalliSJ

Some studies show a positive correlation between both neuropathy harshness and poor glycemic control with both the consequence and intensity of DNP pain, relation with genetic predisposition that accurate ion channel variants may be inclined to the progression of painful DNP (P