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Mol Aspects Med 25(56):455473 El-Hattab AW, Scaglia F (2015) Disorders of carnitine biosynthesis and transport

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During ischemia, overstimulation of NMDA receptors by glutamate and glycine triggers pathological calcium influx, leading to mitochondrial calcium overload and subsequent mitochondrial permeability transition pore (mPTP) opening, further initiating apoptotic cascades [144] (Fig

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