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When the ER:ER ratio was high, NPY transcription was repressed

Initial results from early randomized placebo-controlled studies such as the Women's Health Initiative suggesting that HRT increased the risk of coronary heart disease and breast cancer across the board in postmenopausal women were inappropriately interpreted and communicated with the public, leading to sharp declines in HRT prescriptions (115, 116)

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We propose here that the mechanism by which MGO causes cognitive impairment is through microvascular impairment and BBB integrity loss

Finally, we extend our heartfelt appreciation to the patients and their families for their willingness and generosity in participating in this study