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Likewise, it takes a long time to replenish these B12 stores

Recalls & Warnings August 21, 2019 Large Multivitamin, Calcium Pills Can Be a Choking Hazard for Older Adults Approximately 19% of adverse events associated with dietary supplements involve swallowing problems, especially choking, and this is mostly likely to occur in adults age 65 or older, according to a new report published in the Annals of Internal Medicine

The type of B12 supplement might matter too

A preliminary study found that the vaccine seems to offer strong protection about 10 days after the first dose, compared with people taking a placebo

Starting at 250-300mcg regardless of body weight, then adjusting based on response, often works better than jumping to weight-based higher doses