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Several mechanisms can prevent the inflammatory or autoimmune phenomena triggered by gut-originated gluten peptides: Gluten withdrawal will eliminate or attenuate the harmful inflammatory, immunogenic, oxidative, stressogenic, dysbiotic, metabolic, and cellular consequences described in Table 1

However, a study has focused chiefly on anti-inflammation and immune-modulating benefits

However, another study posits that brequinar's sensitizing effect on ferroptosis is actually accomplished via FSP1 inhibition and not via DHODH [284], as in the earlier study exceedingly high concentrations of brequinar were used, which easily inhibit FSP1

Accordingly, conventional plate readers can only cover the ischemic phase and are not suited to mimic reperfusion injury
Targeting astrocyte-mediated glutamate transport (e.g., enhancing GLT-1 function) or lactate shuttling (e.g., activating MCT1/2 transporters) represents a promising therapeutic strategy to preserve neuronal bioenergetics and slow disease progression (Yang et al., 2024)
