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It binds to KRAS G12C mutants and locks KRAS in an inactive state, thereby irreversibly inhibiting KRAS activity

In contrast, HIF2 KO cells presented an accumulation of GSSG, indicating reduced capacity to overcome radiation-induced oxidative stress (Figure S7B)

Saudi Pharmacol J

doi: 10.1016/j.ebiom.2019.04.041 56 NallanthighalSRadaMHeisermanJPChaJSageJZhouBet al
