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In both BDL and lithocholic acid-treated Huh-7 cells, the fall in expression of GSH synthetic enzymes coincided with an increase in the expression of several Maf proteins (c-Maf, MafG and MafK) as well as increased c-Maf and MafG nuclear binding to ARE

Li et al., 2020)

This safety record does not constitute approval for human use but is relevant context for researchers evaluating preclinical compounds

In CLL, biallelic loss of the ATM gene in cases with 11q deletion (del(11q)) is associated with poor prognosis, and CRISPR-generated isogenic models revealed a therapeutic vulnerability to combined BCR and PARP inhibition, with synergistic effects confirmed ex vivo in primary patient samples, suggesting a promising strategy for high-risk CLL [114]

doi: 10.3390/antibiotics11010040 164 HataJ.ArimaH.RothwellP