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Castillo, JJ

The marked increases in protein levels of BNIP3, P62, and PARKIN were clearly observed in the tibialis anterior muscle of mice with castration (112), and the increased ratio of LC3 II/LC3 I in mice with hypogonadism, which indicates a strong association between androgen deficiency and enhancement of mitophagy (113)

The body can only absorb just so much at once and, besides, excess intake is unlikely to add benefits

Conclusions Organic acid metabolism disorders usually arise from enzyme deficiencies involved in amino acid degradation, resulting in the accumulation of organic acid in the brain and other tissues
