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Nomura, K., Imai, H., Koumura, T., Arai, M

Key toxicities to watch: Myelosuppression infections, bleeding risk Mucositis & diarrhea GI toxicity Hand-Foot Syndrome skin redness, pain, peeling (esp

doi: 10.1016/S0021-9258(19)77923-X

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In prolonged exercise, as glycogen stores deplete, the liver shifts to ketogenesis by upregulating 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) and -hydroxybutyrate dehydrogenase (BDH1), producing BHB, which is alternative energy source for both the brain and muscle [59,60]