glutathione depletion and methylation block Synthesis Explained: How Your Body Builds Its Master Antioxidant Ferroptosis in Cancer: Epigenetic Control

While the mechanism of the canonical reaction was uncovered decades ago, new studies are highlighting the myriad of regulatory mechanisms presented to this enzyme

Epigenetics in Psychiatry: Elsevier

10.3389/fonc.2022.913669 274 ZhangX.SuiS.WangL.LiH.ZhangL.XuS.et al (2020)

In cultured cardiomyocytes, DOX concentrates in mitochondria, increasing mitochondrial iron deposition and ROS levels, and dexrazoxane has demonstrated efficacy in reversing DOX-induced cardiomyopathy by lowering mitochondrial iron levels

It is important to have proper testing done to confirm a B12 deficiency so you can establish an appropriate treatment plan to increase levels of B12 in the body