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doi: 10.1021/jf0525941 583 LazarusSAHammerstoneJFAdamsonGESchmitzHH

[DOI] [PubMed] [Google Scholar] 66.Radwan M.O., Kadasah S.F., Aljubiri S.M., Alrefaei A.F., El-Maghrabey M.H., El Hamd M.A., Tateishi H., Otsuka M., Fujita M

Possible side effects may include mild gastrointestinal symptoms such as nausea, abdominal discomfort, bloating, or loose stools

Since the inhibition of ASK1 (apoptosis signal-regulation kinase 1) in NLRP3 (NOD-like receptor thermal protein domain associated protein 3) mutant mice can reduce liver fibrosis, hepatocyte death, and liver TNF- expression, it suggests the application prospects of ASK1 inhibitor selonsertib in liver diseases