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The observation that FLNA 2124 which does not abolish the interaction of SSTR2 with endogenous FLNA, was able to block the apototic effects of SST2 and the SST2-mediated ERK1/2 inhibition suggests that the FLNA scaffold properties are required for the assembly of signal transduction complexes

The study used 36 male Sprague-Dawley rat pup, exposed to 250 mg/kg PPA to induce ASD-lke features, and pre-treated for 27 days with either yogurt, artichoke extract (400 mg/kg), luteolin (50 mg/kg) or Lacticaseibacillus rhamnosus GG (0.2 mL/day)

Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion

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Find out more about the methylfolate pathway here