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(2020) found that ferroptosis inducer Ras-selective lethal small molecule 3 treatment exacerbated the disease symptom, including hepatic steatosis and inflammation, which could be restored by the intervention of ferroptosis inhibitors

Int J Pharm Pharm Sci 8:6976 Fujii H, Kawada N, Nafld JSGO (2020) The role of insulin resistance and diabetes in nonalcoholic fatty liver disease

[11] Clinicians should avoid administration in patients with known hypersensitivity to ethanolamine antihistamines, narrow-angle glaucoma, symptomatic prostatic hypertrophy, stenosing peptic ulcer, bladder-neck obstruction, or severe chronic obstructive pulmonary disease, as peripheral antimuscarinic effects can precipitate urinary retention, acute angle closure, or bronchial thickening

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This, in turn, leads to reduced brain tryptophan concentration, decreased 5-HT levels, and diminished 5-HT receptor binding, which may underlie the 5-HT system dysfunction, impaired neurotransmission, and negative cognitive effects observed in SZ