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CircRNAs play important roles when they are translated into proteins

The degenerative process of intervertebral discs is often accompanied by the overexpression of matrix metalloproteinases (MMP3, MMP13) and inflammatory factors (IL-1, IL-6, IL-8, PEG2, TNF-) (Wang et al., 2020)

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Such substances as EGCG, curcumin, resveratrol, and genistein have shown their capacity to reverse abnormal epigenetic alterations linked to the activation of oncogenes and the inhibition of tumor suppressor genes

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