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These include the piriformis, obturator internus, quadratus femoris, superior & inferior gemellus (FIGURE 2)

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Besides the solubilization of a drug by physical encapsulation, polymeric micelles can be loaded with hydrophobic molecules that are conjugated or complexed with the polymeric backbone (63)

The functional assays of CYP3A4 further validate this claim: iHLOs exhibited a concentration-dependent inhibition profile following ketoconazole treatment (IC 50 : 0.83 M), comparable to HepaRG cells but distinct from PHHs

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