Frontiers
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It is noteworthy that baicalein, baicalin, chrysin, and vitexin have been shown in preclinical animal models to treat CNS diseases by inhibiting ferroptosis (Table 3), with their chemical structures illustrated in Figure 6A
doi: 10.1186/1742-2094-9-5
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In addition, it has been observed that genetic polymorphisms of CTLA-4 and PD-1 genes may also increase the incidence of immunotherapy-induced hypophysitis and other autoimmune diseases (103, 104)
