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These drugs reduce ROS generation through multiple mechanisms: by enhancing mitochondrial biogenesis and fusion (via PGC-1), activating cAMP/PKA and PI3K/Akt pathways, increasing expression of antioxidant enzymes such as SOD2 and catalase, and restoring endothelial NO bioavailability [449,450]

CJC-1295 (without DAC) stands as an exceptional example of rational peptide design and pharmaceutical development, representing a sophisticated molecular tool that has transformed growth hormone research by providing researchers with the ability to enhance and extend natural GHRH signaling while preserving essential physiological pulsatile patterns

Additionally, SGLT2 inhibitors reprogram macrophage metabolism by downregulating the glycolytic enzyme PFKFB3, facilitate the transition from M1 to M2 phenotype, and indirectly inhibit lipid accumulation in hepatocytes (176)
Invest Ophthalmol Vis Sci 56(12):73037311 Singh S, Singh S, Kumar A (2022) Systemic Candida albicans infection in mice causes endogenous endophthalmitis via breaching the outer blood-retinal barrier
