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Glutathione is tripeptide that is present in nearly all living cells mainly in the cytosol with the highest concentration in the liver compared to other tissues of the body [4]

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Deficiency of VitB12, various inborn errors that can affect the absorption (such as IF deficiency and ImerslundGrsbeck syndrome), the transport (transcobalamin deficiency), and the intracellular metabolism of VitB12 (combined methylmalonic acidemia and homocystinuria depending on the genes involved), rely on a specific requirement of supplementation/treatment with VitB12 that allow patients to survive and, in some cases, improve neurological impairments