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10.2174/1567205015666180904154446 [DOI] [PubMed] [Google Scholar] Wilson E

Alanbaei M, Abu-Farha M, Hebbar P, Melhem M, Chandy BS, Anoop E, Cherian P, Al-Khairi I, Alkayal F, Al-Mulla F et al

PMID: 17024233

2 , 19 , 32 , 53 , 79 , 80 This strong ectoenzyme inhibition makes isatuximab more effective in overcoming ADOmediated immunosuppression in the MM hypoxic tumor microenvironment, which promotes ADO generation predominantly through the CD38/CD203a/TRACP pathway

First identified in 2015, it belongs to a distinct group of mitochondrial-derived peptides (MDPs), acting as signaling molecules from mitochondria to the cell nucleus