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Thus, the authors state that TB4 may be capable of re-activating embryonic processes.29 December 2021 review A 2021 review covers the results of a few human TB4 trials

Rho/Rho-kinase pathways have also been implicated in ASM hyperresponsiveness and remodeling, mediated in part through unidentified stretch-sensitive ion channels (190192)

The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning)
Several factors contribute to the development of hyperpigmentation, with sun exposure being the primary culprit in most cases

10.1046/j.1440-1789.2002.00438.x 103
