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Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimers disease patients

Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response

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This indicates that the beneficial clinical effects observed after repeated dosing can not be ascribed to an accumulation of NAC in plasma

A particular advantage for revealing this concept (i.e., BPC 157 therapy, a native cytoprotective gastric pentadecapeptide, not degraded in human gastric juice, safe (lethal dose (LD1) not achieved), no adverse effect in clinical trials (i.e., ulcerative colitis) (for a review, see [6,18,19])) in practice, and in the spinal cord injury, in particular, is its very safe profile