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3 The risk factors for methotrexate AEs include higher doses (3.5 g/m 2 ), rapid infusions, preexisting kidney impairment, older age (aged 50 years), and the concurrent use of medications that are nephrotoxic or that impair methotrexate clearance (eg, proton pump inhibitors, aminoglycosides, nonsteroidal anti-inflammatory drugs, penicillin and penicillin derivatives, amphotericin, probenecid)

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Through the intake of nutrients from the outside, we ultimately synthesize adenosine triphosphate (ATP) in mitochondria.ATP provides energy to our body and participates in regulating metabolic activities, maintaining the normal functioning of living systems

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Therefore, the changes in the myelination and lesion extent in these two groups will be due to the UA treatment

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